The Relevance Of Clodronate Liposome In Medical Science

By Roxanne Cruz


Perhaps medical science is the best industry in science because of the it made possible the inventions and discoveries that was once only imagined. Different solutions were found to cure different diseases acquired from viruses and bacteria. For example, thousands of residents died because yellow fever has got no medicine. But overtime, because of these hard working discoverers, vaccine for the fever was invented. Clodronate liposome is surely one of discoveries that is going to play a significant role in medicine industry.

Clodronate disodium or clodronic acid, or known commonly as clodronate is the first generation of bisphosphonate without nitrogen. It is a medicine and is approved to be used for the prevention and treatment of osteoporosis cases to women who are at their post menopausal stage. It is also said to deplete macrophages.

Macrophages are white blood cells inside tissues. They are produced through division of monocytes, a type of white blood cell which was formed in the bone marrow and spleen which ingests particles of cell and huge foreign particles. So basically macrophage is the center of immune system. It defends the body from any invasion of different kinds of parasites and foreign transplant.

Liposomes, in cell biology, are the microscopic sac that are composed of fatty liquids. They are used in the experimental research of the cell. It can be supplied with drugs used in curing cancer and other diseases. It usually contained of liquid solutions and composed of phospholipids.

Science discovered clodronate liposome acts for the suppression of the macrophage. Indeed immune system defends the invasion of infectious viruses and bacteria. Through immune response, it will attack the invaders that will cause diseases to the organ or body. However, the immune system can be the source of disease in the body.

In most circumstances, the immune system helps the body cope up diseases like fever and colds. However, when it is damaged, it will attack all the cells including the healthy ones. With a stroke of misfortune, several grave disorders will take place.

As mentioned earlier, immune response protects the body from viral invasion. However, several damages will lead to grave autoimmune medical conditions caused by transplant rejection. This transplant rejection is one of the effects of the response. As a new organ in places on the transplant patient, cells will incite the system to attack the organ cells that will lead to rejection.

Because of the autoimmune disorders that could actually happen, here comes the discovery of the mighty liposome. This is composed of bisphosphonate and will deplete macrophages. After it was transported, macrophage will detect that it is alien. In result, it will engulf it through the thing so called phagocytosis.

Clodronate liposome also helps to improve anti tumor effects caused by anti tumor drugs during cancer. This may not be able to cure the disease but somehow it will increase plasma absorption. Though this discovery is of great significance in the medical science, before actually resorting in taking it, consult you doctor first.




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